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Open access Oct 2026

Interactions of Glucagon-Like Peptide-1 Receptor Agonists With GLP-1R-Gs Complex: Insights From Gaussian-Accelerated Molecular Dynamics.

The glucagon-like peptide-1 receptor (GLP-1R) is a critical therapeutic target for metabolic diseases. GLP-1 receptor agonists (GLP-1RAs) have been developed to treat type 2 diabetes and promote weight loss. In this study, Gaussian accelerated molecular dynamics (GaMD) simulations, MM-PBSA calculations, and conformatio...

Xue Zhou, Ming-Hao Liu, Yun-Lai Shi et al. · 0 citations
Open access Aug 2026

The KAT8-CDK1 K33 acetylation axis drives doxorubicin resistance by suppressing ferroptosis and apoptosis in breast cancer

KAT8-dependent CDK1 K33 acetylation is established as a key epigenetic mechanism sustaining anthracycline resistance and targeting the KAT8-CDK1 axis may provide a therapeutic strategy to overcome refractory breast cancer.

Qing-Zhi Zhao, Qi-Xian Zou, Jin-Meng Chu et al. · 0 citations

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