Open access
Sep 2026
J-domain proteins stimulate PKL-mediated chromatin compaction at H3K4-hypomethylated genomic loci
Chromatin accessibility varies widely across distinct genomic regions in eukaryotes, yet the mechanisms governing these differential patterns remain poorly understood. Here, we identify a subfamily of functionally redundant J-domain proteins (JDPs) that assemble into a protein complex with PICKLE (PKL), an evolutionari...
Bin-Bin Guan, Zi-Juan Yan, Ping Du et al.
· bioRxiv · 0 citations