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The circadian system, an evolutionarily conserved endogenous oscillator coordinating physiological adaptation to geophysical cycles, coordinates hierarchical gene regulatory networks, metabolic pathways, and physiological functions to maintain organismal homeostasis. Circadian disturbances caused by modern lifestyle ar...
This review synthesizes current understanding of the multilayered regulatory networks controlling HY5, ranging from constitutive photomorphogenic 1/suppressor of phytochrome A (COP1/SPA)-mediated ubiquitin-dependent degradation, transcriptional regulation by upstream factors, and extensive post-translational modificati...
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