Author

Ying-Hao Han

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Open access Oct 2026

PRDX1 as a Redox Gatekeeper at Mitochondrial-ER Contact Sites: Implications for Kidney Fibrosis Progression and Therapy

Peroxiredoxins (PRDXs) constitute a class of thiol-dependent oxidoreductive regulatory factors whose functions extend beyond peroxide detoxification to include the regulation of oxidoreductive signaling, organelle homeostasis, and cell fate determination. The emerging role of PRDX1–6 in fibrotic diseases—particularly P...

Yang Zhang, Jaeyeon Lee, Nan-Nan Yu et al. · Antioxidants · 0 citations

Open access Sep 2026

Peroxiredoxin II as a metabolic gatekeeper against aflatoxin B1-induced hepatic steatosis: restoration of PPARα/γ balance via mitochondrial ROS scavenging

Aflatoxin B1 (AFB1), a pervasive food contaminant affecting approximately 25% of global staple crops, represents an underrecognized environmental risk factor for nonalcoholic fatty liver disease (NAFLD). This study investigates the protective role of peroxiredoxin II (Prx II), a mitochondrial antioxidant enzyme, agains...

Wen-Jia Xu, Xin-Yue He, Hao-Cheng Liu et al. · Mycotoxin Research · 0 citations