Open access
Jul 2026
CACUL1 promotes hepatocellular carcinoma progression through enhanced tumor cell proliferation and macrophage-mediated immune suppression
CACUL1 functions as a dual-axis oncogenic driver in HCC through enhanced tumor cell proliferation associated with PI3K/AKT signaling and immune evasion via Notch1-dependent macrophage polarization, positioning it as a candidate prognostic biomarker and therapeutic target.
Xing Wang, Yuhan Tan, Ju Wang et al.
· Frontiers in Immunology · 0 citations