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Open access Sep 2026

Comparing Missing Data Strategies for Generalized Pairwise Comparisons in Randomized Clinical Trials: A Simulation Study

Generalized pairwise comparisons are increasingly being used in randomized clinical trials. This study evaluates how missing data strategies impact the operating characteristics of endpoints combining overall survival and a longitudinal outcome. A simulation study was conducted to evaluate the impact of censoring and m...

R. V. van Eijk, Ying Lu · 0 citations
Preprint Sep 2026

RECaST-Surv: A Calibrated Borrowing Method for Survival Endpoints in Unequal Randomized Trials

Randomized trials with limited concurrent control information---including but not limited to unequal-randomization settings---can offer ethical and practical advantages, especially in pediatric and rare diseases, but they often lose power because fewer control patients are available for direct comparison. Borrowing inf...

De-Hua Bi, Arlina Shen, R. V. van Eijk et al. · 0 citations

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