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Author

Ying-Nan Wang

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Open access Sep 2026

Discovery and Optimization of AMT‐676, a CDH17‐Targeting ADC for the Treatment of Advanced Gastrointestinal Cancers

ABSTRACT Advanced‐stage gastrointestinal (GI) cancers present an unmet need for innovative therapies, and antibody‐drug conjugates (ADCs) offer promising solutions. This study investigates the antitumor efficacy and toxicity of AMT‐676, a novel ADC targeting Cadherin 17 (CDH17), in GI cancers. Utilizing MabArray screen...

Ying-Nan Wang, Dan-Yun Ruan, Jing Shi et al. · 0 citations
Review Open access Jul 2026

Molecular mechanisms, current therapeutics, and emerging strategies in esophageal cancer: A comprehensive review.

This review systematically categorizes and synthesizes findings from key EC clinical trials conducted over the past five years and integrates the current understanding of molecular pathogenesis, targeted therapeutic approaches, the tumor immune microenvironment, and emerging treatment strategies.

Ying-Nan Wang, Xiao-Wen Lian, Yu-Kun Chen et al. · 0 citations

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