Open access
Aug 2026
BoYueGRN: Zero-shot causal discovery of directed gene regulatory networks from single-cell transcriptomes via amortized inference over synthetic structural causal models
BoYueGRN reframes directed GRN inference as a train-once, reuse-across-datasets paradigm, which opens the door to systematic, atlas-scale mapping of regulatory dynamics across human diseases.
Jingyue Wu, Ying-Qiang Shen
· bioRxiv · 0 citations