Author

Ying Sun

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Open access Aug 2026

Cell-specific cPGES control of glucocorticoid receptor function drives MASLD progression.

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disorder and progresses through distinct pathological stages whose specific drivers remain unclear. Here we show that cytosolic prostaglandin E synthase (cPGES) drives MASLD progression in a cell-type-specific, prostagl...

Dan-Dan Zhong, Ranran Qiao, Guo-Gui Quan et al. · Cell Reports · 0 citations

Open access Oct 2026

METTL14‐Mediated m6A Methylation Preserves Cardiomyocyte Homeostasis and Attenuates Progeria‐Associated Cardiac Remodeling

Hutchinson–Gilford progeria syndrome (HGPS) is a rare premature aging disorder most commonly caused by a de novo synonymous mutation (c.1824C>T) in the LMNA gene. This mutation activates aberrant splicing of prelamin A, leading to the production and accumulation of progerin, which drives accelerated aging, with patient...

Shi-Xiao Wang, Jie Zhang, Ying Ao et al. · Aging Cell · 0 citations