Exploration and Evaluation of PEGylation and Aromatic Substitution of Covalent FAP-Targeted Radiopharmaceuticals: Preclinical and Preliminary Clinical Studies
Fibroblast activation protein (FAP) is an attractive target for cancer theranostics; however, currently available FAP-targeted radiopharmaceuticals often exhibit rapid clearance and insufficient tumor retention. In this study, we designed two covalently modified FAP-targeted radiotracers, [68Ga]Ga-T1 and [68Ga]Ga-T2,...