Open access
Aug 2026
Integrated multi-omic analysis of pediatric metastatic osteosarcoma reveals endothelial cell plasticity and lineage infidelity
Findings reveal substantial plasticity among endothelial and osteosarcoma cells in human and murine metastatic osteosarcoma, provide new insight into the how the metastatic microenvironment shapes the tumor vasculature, and challenge current models of osteosarcoma biology.
Julian Burks, Ying Wu, Krithika Bhuvaneshwar et al.
· bioRxiv · 0 citations