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Open access Sep 2026

N-salicyloyl tryptamine derivatives as potential therapeutic agents for doxorubicin-induced hepatotoxicity via PI3K/AKT/HO-1 signaling pathway

Doxorubicin (DOX) is a broad-spectrum antineoplastic agent with remarkable efficacy against various malignant tumors. However, its clinical application is severely limited by profound hepatotoxicity, wherein oxidative stress acts as a pivotal mechanism underlying DOX-induced hepatotoxicity. N -salicyloyl tryptamine...

Yu-Ting Zhao, Jing Zeng, Guang-Long Pang et al. · 0 citations
Open access Sep 2026

An Engineered Biomimetic Nanoreactor With Cascade Functions for Targeted and Combinatorial Therapy of Ischemic Stroke.

Ischemic stroke reperfusion injury is driven by oxidative stress and neuroinflammation, but current neuroprotective strategies suffer from poor targeting, limited functionality, and low blood‑-brain barrier (BBB) penetration. Herein, a multifunctional nanoplatform (RM@HPAN) is constructed: a hollow mesoporous Prussian...

Shao-Fa Li, Ying Wu, Hui-Min Wei et al. · 0 citations

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