Open access
Sep 2026
Targeting BIRC6 rejuvenates hematopoietic stem cell aging and immunosenescence
It is revealed that regulatory T cells within the bone marrow microenvironment actively safeguard the survival of aged HSCs via a previously uncharacterized signaling pathway, and targeted BIRC6 inhibition in HSCs using antibody-conjugated lipid nanoparticle-encapsulated antisense oligonucleotides (LNP-ASOs) significan...
Wei-Nian Liao, Fang-Ze Shao, Shao-Yan Wang et al.
· Signal Transduction and Targ... · 0 citations