Author

Ying Yu

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Jul 2026

Integrating Network Pharmacology, Bioinformatics, Transcriptome Sequencing, And Experiments To Explore Mechanisms of Danggui Shaoyao San Against Breast Cancer.

INTRODUCTION/OBJECTIVE Breast cancer is one of the most common malignant tumors in women worldwide, and Danggui Shaoyao San (DGSY San) is commonly used in the clinical treatment of breast cancer. METHODS This study integrates UHPLC-QE-MS/MS, network pharmacology, transcriptomics, and in vitro experiments to explore the mechanism of DGSY San's anti-breast cancer effects. RESULTS Mass spectrometry identified 70 active ingredients. Network analysis predicted that it regulates apoptosis and proliferation through the MAPK pathway. in vitro experiments showed that DGSY San inhibited the proliferation, migration, and invasion of MCF-7 cells in a concentration-dependent manner and induced G2-phase arrest and apoptosis. Transcriptome sequencing and comprehensive analyses of network pharmacology and clinical databases simultaneously confirmed enrichment of the MAPK pathway. Western blot confirmed that it downregulated p-p38 and p-ERK phosphorylation and promoted the expression of apoptosis-related proteins. DISCUSSION The results indicate that DGSY San inhibits breast cancer proliferation and induces apoptosis through the MAPK pathway. CONCLUSION This study developed a multidimensional, integrated analysis model of "components-transcriptome-clinical data" to systematically elucidate the mechanisms underlying TCM prescriptions.

Jing Wang, Li Zhang, Ying Yu et al. · Current Medicinal Chemistry · 0 citations

Aug 2026

Non-linear association of blood urea nitrogen with low cognitive performance: Translational evidence from murine models and human population analysis.

BACKGROUND Cognitive impairment in Alzheimer's disease (AD) is increasingly recognized as a systemic metabolic disorder, yet early peripheral biomarkers remain elusive. The kidney-brain axis offers a novel perspective, but the association between blood urea nitrogen (BUN) and Cognitive function is poorly understood. METHODS We integrated murine models (5xFAD vs. wild-type), human NHANES data (n = 3435), and single-cell virtual knockout of the BUN-associated gene GLS in human kidney cells. RESULTS 5xFAD mice showed early renal histopathological damage and memory deficits; BUN positively correlated with fear memory retention, and reduced BUN in 5xFAD aligned with the low-BUN risk limb of the human non-linear association. In humans, restricted cubic splines revealed a significant inverse association between BUN and low cognitive performance (LCP), with the risk reduction plateauing at BUN levels above approximately 12 mg/dL. Subgroup analyses showed no significant interactions for any of the examined variables, indicating that the inverse association between BUN and LCP was consistent across population strata. Exploratory GLS knockout upregulated mitochondrial oxidative phosphorylation and ROS pathways, providing hypothesis-generating molecular clues. CONCLUSIONS Cross-species evidence links BUN to cognitive, with murine data consistent with human low-BUN risk and identifying a significant inverse association between BUN and LCP that plateaued above approximately 12 mg/dL in this older adult cohort in this cohort, which should be viewed as exploratory and requires validation in independent prospective cohorts. Virtual GLS knockout suggests a mitochondrial axis. BUN warrants further evaluation as an accessible biomarker for cognitive risk assessment.

Rong-Jiang Zhang, Tianhao Yu, Kai Hao et al. · Experimental Neurology · 0 citations