JQ-1 attenuates microglial activation and retinal pathology in experimental diabetic retinopathy with modulation of Pagr1a/JAK2/STAT3 signaling.
Diabetic retinopathy (DR) is a major vision-threatening complication of diabetes mellitus, in which chronic inflammation and retinal microglial activation contribute to disease progression. Bromodomain-containing protein 4 (BRD4) is an epigenetic regulator involved in inflammatory transcription; however, the downstream...