Dengue virus (DENV) is a mosquito-borne orthoflavivirus that infects millions of people annually across tropical and subtropical regions, posing a severe and growing threat to global public health. Currently there are no antiviral drugs available for DENV infection. The methyltransferase domain of non-structural protei...
Chen-Chen Li, Jian-Fang Zhang, Yue-Gao Hu et al.· International Journal of Bio...· 0 citations
ABSTRACT Influenza A virus (IAV) commandeers host transcriptional machinery to replicate, but mechanisms remain elusive. CRISPR screen identifies PARP1 as a proviral factor that binds viral NS1. ATAC‑seq reveals IAV drives PARP1‑dependent chromatin remodeling at promoter‑proximal regions (−100 to +300 bp), linking PARP...
Shu-Feng Ma, Chang-Yuan Kang, Xi-Xian Liu et al.· Advancement of science· 0 citations
Morpholino nucleosides play an important role in medicine as building blocks for antisense oligonucleotide drugs (PMOs), but their therapeutic applications as nucleosides are still unexplored. A novel library of 38 fused bicyclic morpholino-uridine and -adenosine derivatives was constructed through an innovative, sin...
Rasha Ghanem Kattoub, M. Bege, Erika Mező et al.· ACS Bio & Med Chem Au· 0 citations
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