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Author

Yingjun Li

3 papers indexed here

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Sep 2026

Bioluminescence-based high-throughput screening and identification of direct-acting dengue virus NS5 methyltransferase inhibitors.

Dengue virus (DENV) is a mosquito-borne orthoflavivirus that infects millions of people annually across tropical and subtropical regions, posing a severe and growing threat to global public health. Currently there are no antiviral drugs available for DENV infection. The methyltransferase domain of non-structural protei...

Chen-Chen Li, Jian-Fang Zhang, Yue-Gao Hu et al. · 0 citations
Open access Sep 2026

NS1‐Induced PARP1 Phase Transitions Prolongs Host Transcriptional Pausing to Promote Influenza A Virus Replication

ABSTRACT Influenza A virus (IAV) commandeers host transcriptional machinery to replicate, but mechanisms remain elusive. CRISPR screen identifies PARP1 as a proviral factor that binds viral NS1. ATAC‑seq reveals IAV drives PARP1‑dependent chromatin remodeling at promoter‑proximal regions (−100 to +300 bp), linking PARP...

Shu-Feng Ma, Chang-Yuan Kang, Xi-Xian Liu et al. · 0 citations
Open access Sep 2026

New Class of Uridine- and Adenosine-Based Morpholino Nucleosides as Potential Anti-SARS-CoV-2 Agents: Synthesis, Antiviral Evaluation, Molecular Modeling, and In Silico ADMET Properties

Morpholino nucleosides play an important role in medicine as building blocks for antisense oligonucleotide drugs (PMOs), but their therapeutic applications as nucleosides are still unexplored. A novel library of 38 fused bicyclic morpholino-uridine and -adenosine derivatives was constructed through an innovative, sin...

Rasha Ghanem Kattoub, M. Bege, Erika Mező et al. · 0 citations

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