Aug 2026
Triazine Linchpins for Selective Lys-Lys Stapling of Unprotected Peptides.
Peptide stapling exerts profound effects on key peptide properties, including metabolic stability, cell membrane permeability, and conformational constraint. Herein, we report a mild and efficient 2,4-dichloro-1,3,5-triazine-mediated stapling strategy for the selective cross-linking of lysine side-chain amines. This ap...
Peiru Chen, Anhui Mao, Jingxiu Xu et al.
· Organic Letters · 0 citations