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Yingying Chen

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Open access Aug 2026

Targeting a candidate stromal immune checkpoint: a cellular senescence signature identifies COMP⁺ cancer-associated fibroblasts associated with CD8⁺ T-cell exclusion via a predicted COMP-CD47 axis in colorectal cancer.

INTRODUCTION Resistance to immunotherapy in colorectal cancer (CRC) is closely linked to an immunosuppressive tumour microenvironment (TME), in which cancer-associated fibroblasts (CAFs) are key regulators. Cellular senescence and the senescence-associated secretory phenotype (SASP) are increasingly recognised as drive...

Yingying Chen, Ying Zhang, Chi Lv · 0 citations

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