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Author

Yining Zhu

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Aug 2026

Engineering Lipid Nanoparticles through Integrated Compositional and Ligand Targeting Enhances β Cell-Directed RNA Delivery.

A dual-targeting LNP engineering strategy that integrates high-throughput compositional screening with surface conjugation of β cell-specific targeting ligands to enable selective gene delivery to pancreatic β cells is developed and establishes a versatile platform for RNA therapeutics and gene-editing applications in...

Di Yu, Yining Zhu, A. Roca-Rivada et al. · 1 citation
Jul 2026

Stabilizing Anionic mRNA Lipid Nanoparticles by Cleavable Crosslinking of Cholesterol.

Lipid nanoparticles (LNPs) are the leading platform for mRNA delivery, with their in vivo performance governed by lipid composition and colloidal stability. While anionic helper lipids can bias LNP expression toward the spleen, weak RNA-lipid interactions during purification often induce nanoparticle rearrangement and...

Yunhe Su, Joseph Choy, Xiang Liu et al. · 0 citations

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