Penicillium sp. S2014503 is a fungus found in the Antarctic. Herein, we report a new heterocyclic (1) and two semi-synthesized ones (2-3) derived from citrinin (4), the main product of S2014503. Absolute configurations of 1 and 4 were deduced by single crystal X-ray diffraction analyses. Compound 2 was analyzed to be a...
Hai-Bo Zhang, Imran Khan, Wen-Yu Cheng et al.· Journal of Asian natural pro...· 0 citations
This study identifies that upon the elevation of intracellular c-di-GMP levels induced by antibiotic treatmen, the universal stress protein UspG serves as a cryptic, direct c-di-GMP effector in extended-spectrum beta-lactamase (ESBL)-producing strain K. pneumoniae, and indicates that UspG is functionally conserved acro...
Xiao-Xiao Liu, Mingfang Wang, Yi-Kai Fu et al.· PLoS Pathogens· 0 citations
These findings indicated that PABA could be a candidate inhibitor of anthranilic acid signaling to interfere with the QS systems of R. solanacearum to attenuate the virulence and presented a non-antibiotic-based treatment strategy and provided a theoretical basis for the development of novel antibacterial treatment.
Chuanwang Yao, Wanlian Zhang, Zizi Lin et al.· Virulence· 0 citations
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