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Author

Yisheng He

2 papers indexed here

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Review Open access Sep 2026

Planetary health and pharmacology: Addressing the ecological impact and circular threat of pharmaceuticals.

Drug safety science has expanded beyond patient-level pharmacovigilance to address the environmental consequences of pharmaceutical use. Pharmaceuticals are now detected across diverse ecosystems, but traditional single-compound, high-dose toxicological frameworks remain inadequate for evaluating chronic, low-dose, mul...

Yu-Jian Fan, Xiao-Kai Guo, Jiaying Lyu et al. · 0 citations
Review Jul 2026

The long shadow: a toxicological review of chronic exposure, biopersistence, and latent health risks of engineered nanomaterials.

An integrated risk assessment framework is proposed that combines adverse outcome pathway analysis, physiologically-based pharmacokinetic modeling, new approach methodologies, and safe-by-design principles to enable predictive hazard identification and supports evidence-based regulation of existing ENMs while enabling...

Yu-Jian Fan, Jiaying Lyu, Xiao-Kai Guo et al. · 0 citations

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