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Yixue Han

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Open access Aug 2026

Design and synthesis of dual-target CDK9-EZH2 inhibitors using a pharmacophore fusion strategy.

A series of new CDK9/EZH2 dual-target inhibitors are designed by conjugating a self-designed CDK9-targeting fragment with a selective EZH2 inhibitor, and compound A9 demonstrated excellent inhibitory activity.

Yixue Han, Ruiqi Wang, Lina Tian et al. · 0 citations

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