Open access
Jul 2026
Tuberostemonine ameliorates Alzheimer’s disease pathology by suppression of the p38 MAPK signaling pathway
Summary Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder with limited therapeutic options. Here, we report that tuberostemonine (Tub), an alkaloid from Stemona tuberosa, exerts neuroprotective effects in AD models. In Aβ1-42-treated PC12 cells, Tub reduced cytotoxicity, apoptosis, and oxidative s...
Yingzhou Li, Xiaoxia Xu, Ziyao Meng et al.
· iScience · 0 citations