Yogin Patel

83 Preclinical Evaluation of LNK001: Stringent AND-Gate Fidelity and Potent Efficacy of a Dual-Antigen CAIX/ENPP3 CAR T Cell Therapy for Clear Cell Renal Cell Carcinoma

The Logic-gated INtracellular networK (LINK) platform, a Boolean AND-gate architecture in which two synthetic receptors are coupled to distinct proximal T cell signaling adapters, is developed, and LNK001, the first clinical candidate from the LINK platform, is the first clinical candidate from the LINK platform.