Open access
Jul 2026
Engineering short-sequence elements for condensate-like assemblies by de novo design
An integrated framework combining generative artificial intelligence, computational prediction, and experimental validation was established and 13 short-sequence elements with low molecular weight and minimal redundancy formed condensates in E. coli, with enhanced protein recruitment compared to native elements.
Di Zhang, Bin-Yun Zhang, Cheng Zheng et al.
· Synthetic and Systems Biotec... · 1 citation