Hypertemperature-Detonated Biomimetic Semiconductor Stromal Bombs for Enhanced Immunotherapy in Pancreatic Cancer.
Pancreatic ductal adenocarcinoma (PDAC) is characterized by "copper avidity", which easily leads to the dysregulation of copper ion homeostasis. It is possible to develop targeted nanodrugs that selectively kill cancer cells via cuproptosis. However, the dense stroma of PDAC acts as an airtight wall, which not only lim...