Sep 2026
FOXO1 inhibition attenuates ferroptosis-like changes and apoptosis in dopaminergic neurons with the involvement of the SREBP1/SCD1 axis in Parkinson's disease.
Oxidative damage-triggered ferroptosis and apoptosis drive the progression of Parkinson's disease (PD). Forkhead box O1 (FOXO1) is a critical modulator of oxidative stress, while its role in PD remains largely unexplored. Here, the FOXO1 inhibitor AS1842856 (AS) was employed to treat the MPTP-exposed mice and MPP+-chal...
Da-Long He, Yue-Tian Wang, Yi-Min Qiu et al.
· Cellular Signalling · 0 citations