Candida albicans biofilms are a major cause of persistent infections and contribute to antifungal resistance as well as limitations in drug delivery. Targeting virulence traits such as biofilm formation and hyphal transition represents an effective strategy for controlling fungal pathogenicity without exerting strong s...
Juyeon Jo, Ziyad Abdelaal, Yong-Guy Kim et al.· International Journal of Mol...· 0 citations
Low toxicity in plant, nematode, and mammalian models highlights bioisosteric N-acyl sulfonamides as promising antivirulence scaffolds for combating S. aureusBiofilm-associated Staphylococcus aureus infections remain difficult to treat using conventional antibiotics.
Yong-Guy Kim, Michelle O'Driscoll, Conor Horgan et al.· Journal of Medicinal Chemist...· 0 citations
Acne vulgaris is a chronic inflammatory skin disorder in which Cutibacterium acnes contributes to disease persistence through biofilm formation, lipid metabolism, and production of inflammatory metabolites within the pilosebaceous unit. Targeting bacterial physiological pathways that sustain these processes represents...
S. Angulmaduwa, G.G. Roshan Pradeep Ratupaskatiye, Yong-Guy Kim et al.· Microbial Pathogenesis· 0 citations
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