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Sponsored Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt

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Yong-Hong Zhou

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Open access Sep 2026

Discovery of novel imidazopyrazine derivative as a KIF18A inhibitor.

KIF18A, a plus-end mitotic kinesin critical for spindle integrity in chromosomally unstable (CIN) tumors, represents a synthetic-lethal target for anti-mitotic therapy. Herein we report the discovery of compound 19d, a novel imidazopyrazine featuring a spiro-bridged amine that potently inhibits KIF18A (IC50 = 52 nM) an...

Wang-Wei Ao, Bin Xu, Yu Zhang et al. · 0 citations

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