Yong Hu

Coordination of Oligonucleotides into Enzyme-Mimetic Nanostructures for Ameliorating Osteoarthritis through Intervening in Articular Cartilage and Subchondral Bone.

Osteoarthritis (OA) is a common degenerative joint disease, characterized by oxidative stress, excessive inflammatory responses, cartilage matrix degradation, and subchondral bone loss. However, a therapeutic strategy that simultaneously addresses these interconnected pathologies remains elusive in current nanomedicine...