Yong-Kang Chen

T-cell dysregulation in systemic lupus erythematosus: a four-layered model from extracellular cues to epigenetic remodeling and therapeutic opportunities.

Systemic lupus erythematosus (SLE) is a heterogeneous, multisystem autoimmune disease in which the breakdown of T-cell tolerance is increasingly recognized as a central and therapeutically tractable event. Herein, we synthesize the spectrum of T-cell abnormalities in SLE and elucidate the underlying molecular mechanism...