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Author

Yong-Lan Ruan

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Review Open access Aug 2026

Comorbid mechanisms of neuroinflammation and astrocytic ferroptosis in neurological disorders: A vicious cycle (Review)

Neuroinflammation and astrocytic ferroptosis form a self-reinforcing vicious cycle across multiple neurological disorders, constituting a core pathological mechanism driving the progression of neurodegeneration, stroke, epilepsy, autoimmune encephalopathy. Initial neuroinflammation activates microglia to release pro-in...

Li Zhang, Di-Jun Wang, Wei-Qi Wang et al. · 0 citations
Review Sep 2026

Astrocytic Multimodal Programmed Cell Death in Ischemic Stroke: Regulatory Mechanisms and Translational Prospects.

INTRODUCTION Ischemic stroke remains a leading cause of disability and mortality worldwide. Current neuroprotective treatments predominantly target neurons and fail to address the complex post-ischemic cell death cascades in astrocytes, the most abundant glial cells in the central nervous system, whose multimodal Progr...

Li Zhang, Yong-Lan Ruan · 0 citations

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