Yong-Lin Ruan

The E3 ubiquitin ligase Fancl negatively regulates zebrafish antiviral immunity against spring viremia of carp virus.

The innate immune response serves as the first line of host defense against pathogenic infections, and its precise regulation is critical for maintaining immune homeostasis. Fanconi Anemia complementation group L (Fancl) is an E3 ubiquitin ligase that plays an essential role in zebrafish ovarian differentiation, but wh...