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Sep 2026

The dynamic connectome in Alzheimer's disease: From static snapshots to a symphony in time-A hypothesis.

The static functional connectivity (sFC) model has established Alzheimer's disease (AD) as a large-scale brain network disorder, yet it rests on a questionable assumption of temporal stationarity. This assumption obscures the brain's intrinsic dynamics, which are essential for flexible cognition. Here, we advance the h...

Liang Xu, Na Wei, Yong Ran · 0 citations
Open access Aug 2026

Syndecan-4 exerts canonical heparan sulfate-dependent and noncanonical heparan sulfate-independent functions that regulate Aβ amyloid homeostasis

Background Heparan sulfate (HS) and heparan sulfate proteoglycans (HSPGs) are components of the amyloid deposits in Alzheimer’s disease (AD) and other amyloidoses. HS and HSPGs are canonically thought to facilitate amyloid deposition by accelerating the aggregation of amyloidogenic proteins and impairing their clearanc...

K. Shim, Yong Ran, Danny Ryu et al. · 0 citations

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