Open access
Sep 2026
The E3 ubiquitin ligase IDOL suppresses PRRSV replication by targeting viral Nsp3 for SQSTM1-mediated selective autophagic degradation
ABSTRACT Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most devastating pathogens affecting the global swine industry. Autophagy plays an important role in both host defense and PRRSV infection. However, the mechanisms by which the host exploits the autophagy pathway to antagonize PRRSV infe...
Jie-Cong Yan, Yu-Han Wu, Hui Xu et al.
· mBio · 0 citations