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Yong-Sheng Zhou

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Open access Sep 2026

PLA/nHA nanocomposites and metformin rescue aged bone repair by restoring PCK2-regulated mitochondrial metabolism

Bone regeneration declines with age in part because osteoblasts lose mitochondrial metabolic fitness, a defect that conventional osteoconductive scaffolds do not address. The metabolic dysfunction that connects osteoblast senescence to failed repair, however, remains poorly defined. Here, we identify mitochondrial...

Mu-Xin Yue, Hui-Ping Ma, Yong-Sheng Zhou et al. · 0 citations

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