Chlorination-Driven BODIPY Fluorescent Probes for the Selective Monitoring of Myeloperoxidase Activity in Cells and Inflamed Mouse Models.
Myeloperoxidase (MPO) generates hypochlorous acid (HOCl), a major oxidant in inflammatory biology and an increasingly recognized pathogenic mediator and therapeutic target in oxidative and inflammatory diseases. However, selective detection of MPO activity remains challenging because most HOCl-responsive fluorescent pr...