Aug 2026
TRPM7 exacerbates testicular ischemia-reperfusion injury by activating the NLRP3 inflammasome to drive pyroptosis.
A novel TRPM7/NLRP3/pyroptosis axis as a key pathogenic mechanism in testicular IRI is identified, transducing ischemic stress into NLRP3 inflammasome stimulation and inflammatory cell death, positioning it as a prospective therapeutic target.
Xiao Wang, Xiaohong Yin, Yan-Ze Li et al.
· Tissue & Cell · 0 citations