Glutamine, the most abundant amino acid in human serum, serves not only as a key nutrient for maintaining normal cellular biological functions but also as an essential metabolic substrate for the proliferation and survival of tumor cells. Tumor cells exhibit a pronounced characteristic of “glutamine addiction” through...
The global prevalence of metabolic diseases, notably obesity, diabetes mellitus, and thyroid disorders, has risen dramatically in recent decades, posing a significant threat to public health. While conventional pharmacological interventions remain the cornerstone of management, they face considerable limitations, inclu...
Min-Min Xiang, Shuang Liu, De-Sheng Xiao et al.· Signal Transduction and Targ...· 0 citations
It is shown that AP4M1 is markedly upregulated in HCC, correlates with unfavorable prognosis, and is functionally involved in driving HCC progression, providing a critical theoretical basis for AP4M1-targeted therapeutic strategies in HCC.
Yuan-Hao Peng, K. Kang, Xuanxuan Li et al.· Cancer Letters· 0 citations
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