Naringenin from Citrus aurantium L. alleviates loperamide-induced constipation by inhibiting excessive autophagy-mediated apoptosis in interstitial cells of Cajal via the AKT1 signaling pathway.
Constipation is a prevalent gastrointestinal disorder frequently associated with the dysfunction and loss of Interstitial Cells of Cajal (ICCs). Zhishi, the dried young fruit of Citrus aurantium L. (CAL), is a traditional medicine used for constipation; however, its specific bioactive constituents and mechanisms of act...