Open access
Aug 2026
N-glycosylation stabilizes CD155 to evade NK cell surveillance in colorectal cancer
The majority of patients with colorectal cancer (CRC) fail to respond to anti-PD-1/PD-L1 immunotherapy, highlighting an urgent need for alternative immunotherapeutic targets. The immunosuppressive ligand CD155 potently dampens natural killer (NK) cell cytotoxicity via inhibitory receptors, but how CRC cells sustain h...
Jiahe Xu, Dong-Ze Zhang, Kexi Yang et al.
· Cell Death Discovery · 0 citations