Open access
Aug 2026
LARS2 reprograms mitochondrial metabolism and epigenetically upregulates MHC-I to boost antitumor immunity in nasopharyngeal carcinoma
This study uncovers a novel mechanism by which the tumor suppressor LARS2 inhibits immune evasion in NPC through upregulation of MHC-I, and highlights a high-leucine diet as a promising strategy to sensitize tumors to immunotherapy.
Mei Yang, Yongzhen Mo, Dai-Xi Ren et al.
· Journal for ImmunoTherapy of... · 0 citations