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Author

Yoon Soo Chang

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Open access Oct 2026

TREM2+ macrophages mediate anticancer therapy-induced immune evasion in lung adenocarcinoma via the CCL5/CCL22-Treg axis

Introduction Osimertinib and cisplatin are widely used as standard treatments for non-small cell lung cancer (NSCLC); however, their effects on tumor microenvironment remodeling remain poorly understood. This study investigated whether TREM2-positive tumor-associated macrophages (TAMs) promote immune evasion through th...

Chi Young Kim, Y. Cha, Min Kyung Park et al. · 0 citations
Open access Sep 2026

Smoking-Associated Enrichment of CXCL13+ Tfh Cells and VCAM1+ Fibroblasts Is Linked to Tertiary Lymphoid Structure Formation in Lung Adenocarcinoma

Smoking-associated enrichment of CXCL13⁺CD4⁺ Tfh cells was associated with B-cell accumulation and TLS formation in LUAD, and these findings identify the CXCL13⁺ Tfh-B-cell axis, together with VCAM1⁺ fibroblast-rich stromal niches, as potential biomarkers and therapeutic targets in LUAD.

Y. Choi, Chi Young Kim, Eun Young Kim et al. · 0 citations

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