Preprint
Aug 2026
A concentration-independent paradigm rendering weak interactions inherently quantifiable
The affinity-and-geometry readout enabled rational screening for protein-protein-interaction modulators, identifying compounds that enhance weak associations by reweighting local encounters rather than binding tightly on their own or forming a stable ternary complex.
Masahiko Yoshimura, Fuyuki Matsuda, Yoshiki Ikeda et al.
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