Phages and bacteria are engaged in an evolutionary arms race, where phages continually evolve new strategies to overcome bacterial defenses. To systematically investigate the functions of all genes within phage genomes, we constructed a gene deletion library of the
Escherichia coli
phage phiDruSM1, belonging to t...
Shinjiro Ojima, A. Azam, Kohei Kondo et al.· Communications Biology· 0 citations
An RNase-encoding gene is identified that is present in methicillin-susceptible strains, but absent from resistant counterparts, and acts as a barrier to the uptake of mobile genetic elements in Staphylococcus aureus.
Kohei Kondo, A. Azam, J. Hisatsune et al.· Nature Communications· 0 citations
Despite the presence of licensed vaccines and therapeutics, influenza viruses remain a major public health concern, as they cause seasonal respiratory infections and pose a pandemic threat through the emergence of zoonotic strains. Although neutralizing antibodies elicited by seasonal vaccination constitute a primary d...