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Author

Youming Zhang

2 papers indexed here

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Open access Aug 2026

Engineered bacteria as exogenous organelle mimics restore PTEN and p53 tumor suppressor functions for cancer therapy

PTEN and p53 are two pivotal tumor suppressors that synergistically restrain tumor progression but are frequently inactivated in cancer. Restoring their functions is a promising therapeutic strategy but remains limited by unsustainable protein production and off-target effects. Here, we report a biohybrid platform inte...

Shijie Bi, Mao-Qin Wang, Qing Guan et al. · 0 citations
Review Open access Jul 2026

The disorazole family of potent anticancer agents: structures, bioactivity, total synthesis, and heterologous biosynthesis.

This review articulates a paradigm shift in disorazole research: from confronting the extreme challenge of total chemical synthesis towards harnessing programmable biosynthetic engineering (F & Z), and highlights how key technologies have revolutionized the production and diversification of these molecules.

Guoan Fu, He Li, Ruijuan Li et al. · 0 citations

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