Tertiary lymphoid structures in pancreatic cancer: molecular mechanisms, heterogeneity, and clinical significance.
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal solid tumors and is largely refractory to current immunotherapy. Tertiary lymphoid structures (TLS), ectopic immune cell aggregates within the tumor microenvironment, have emerged as candidate biomarkers and therapeutic targets in this setting. This...