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Author

You-You Yan

2 papers indexed here

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Sep 2026

FGF21 inhibits atherosclerosis by reducing endothelial ferroptosis via activation of AMPK/Nrf2 signaling.

BACKGROUND Atherosclerosis is a chronic vascular disease characterized by endothelial dysfunction and lipid accumulation. Ferroptosis, an iron-dependent form of regulated cell death characterized by excessive lipid peroxidation, plays a pivotal role in endothelial injury and the progression of atherosclerosis. Fibrobla...

Dan-Dan Song, Zhen-Zhen Chen, Chao Qi et al. · 0 citations
Sep 2026

Targeting ferritinophagy via NCOA4-FTH1 disruption by sodium tanshinone IIA sulfonate alleviates cardiotoxicity and enhances anti-tumor efficacy.

BACKGROUND Sorafenib remains a first-line therapy for advanced hepatocellular carcinoma (HCC), yet its clinical utility is frequently limited by dose-dependent cardiotoxicity for which no targeted intervention exists. Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, has been imp...

Ying Liu, Xin-Zhong Li, Zi-Ru Dai et al. · 0 citations

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