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Author

Young Nyun Park

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Open access Sep 2026

A refined MASH–HCC model identifies macrophage Gadd45b as a key orchestrator of inflammation-driven neoplastic progression

Metabolic dysfunction-associated steatohepatitis (MASH) is emerging as a leading driver of hepatocellular carcinoma (HCC), yet the molecular mechanisms linking metabolic stress, chronic inflammation and tumorigenesis remain poorly understood. Here we established a metabolically relevant, time-efficient MASH-to-HCC mode...

Hyunmi Kim, Gye-Hyeong Kim, H. Yeon et al. · 0 citations
Open access Sep 2026

Dysregulated m6A via compensatory arginine methylation primes premalignancy in metabolic dysfunction–associated steatotic liver disease

Hepatocellular carcinoma (HCC) originates from premalignant disease-associated hepatocytes (daHeps) that emerge during the progression of metabolic dysfunction–associated steatotic liver disease (MASLD) to metabolic dysfunction–associated steatohepatitis (MASH). As daHeps are compensatorily primed by metabolic stress,...

Geun-Woo D. Kim, Dahee Choi, Soo-Young Kim et al. · 0 citations

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