Author

Yu-Bo Zhang

2 papers indexed here

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Open access Oct 2026

Cellular senescence in ovarian cancer: context-dependent effects on tumor immunity and therapy response

Cellular senescence is a stress-responsive state marked by sustained proliferative arrest and changes in metabolism, chromatin organization, secretion, and immune signaling. In ovarian cancer (OC), platinum therapy and PARP inhibition can generate senescence-associated states with distinct consequences. Their effects d...

Yu-Bo Zhang, Meng-Qi Deng, Jun-Yi Jiang · Frontiers in Immunology · 0 citations

Review Open access Oct 2026

Cellular senescence in ovarian cancer: a proposed geroncogenic shift linking aging, plasticity, and therapy resistance

The geroncogenic shift framework provides a conceptual basis for linking aging biology with tumor evolution and for developing more selective approaches to senescence-directed therapy.

Yu-Bo Zhang, Yue Han, Pin-Zhi Hou et al. · Frontiers in Pharmacology · 0 citations